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Somatotropin, GH, GH-N, Growth Hormone 1, Pituitary growth hormone



What is Growth Hormone

Growth Hormone (GH), also known as somatotropin, is a pleiotropic cytokine of the hematopoietic growth factor superfamily, which encompasses most cytokines, hematopoietic growth factors, and related receptors, and includes the related growth receptor, prolactin, placental lactogens, pro-lifers, and somatostatin (SST).  is primarily recognized for its anabolic role in stimulating the growth and differentiation of muscle, bone, and cartilage.

A number of other functions, including immunomodulatory actions, are also attributed to GH, due in part to the pervasive distribution of its receptors, and the indirect effects associated with GH-stimulated production of insulin-like growth factors (IGFs). Occurring predominantly in the somatotropes of the anterior pituitary, whereupon it is stored in secretory granules, production of has also been noted in many other tissues, including those of the hematopoietic system.

The production and pulsatile release of circulating is very tightly regulated by both negative and positive feedback regulations of pituitary and hypothalamic, such as Pituitary-specific Positive Transcription Factor 1 (POU1F1), Growth Hormone Releasing  (GHRH), and somatostatin (SRIF). Deficient production is associated with dwarfism and reduction of lean body mass, while overproduction is associated with acromegaly and gigantism, as well as breast tumor growth. Recombinant Human is a 22.3 kDa, single, non-glycosylated polypeptide chain containing 192 amino acid residues.


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